Kanow MA, Giarmarco MM, Jankowski CS, Tsantilas K, Engel AL, Du J, Linton JD, Farnsworth CC, Sloat SR, Rountree A, Sweet IR, Lindsay KJ, Parker ED, Brockerhoff SE, Sadilek M, Chao JR, Hurley JB. Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye.  Elife. 2017 Sep 13;6. pii: e28899. doi: 10.7554/eLife.28899. [Epub ahead of print].

Chao JR, Knight K, Engel AL, Jankowski C, Wang Y, Manson MA, Gu H, Djukovic D, Raftery D, Hurley JB, Du J. Human Retinal Pigment Epithelium Cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side. J Biol Chem. 2017 Aug 4;292(31):12895-12905.  [Full Text]


Du J*, Yanagida A, Knight K, Engel AL, Vo AH, Jankowski C, Sadilek M, Tran VT, Manson MA, Ramakrishnan A, Hurley JB, Chao JR*. Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium. Proc Natl Acad Sci U S A. 2016; 113(51):14710-14715.  *Corresponding Author. [Full Text]

Before WVU


Gu H, Carroll PA, Du J, Zhu J, Neto FC, Eisenman RN, Raftery D.Quantitative Method to Investigate the Balance between Metabolism and Proteome Biomass: Starting from Glycine. Angew Chem Int Ed Engl. 2016; 55(50):15646-15650.

Zhang L, Du J, Justus S, Hsu CW, Bonet-Ponce L, Wu WH, Tsai YT, Wu WP, Jia Y, Duong JK, Mahajan VB, Lin CS, Wang S, Hurley JB, Tsang SH. Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J Clin Invest. 2016; 126(12):4659-4673. 

Contreras L, Ramirez L, Du J, Hurley JB,  Satrústegui J, Villa P Deficient glucose and glutamine metabolism in Aralar/AGC1/Slc25a12 knockout mice contributes to altered visual function. Molecular Vision. 2016; 22:1198-1212.

Wu HE, Baumgardt SL, Fang J, Paterson M, Liu Y, Du J, Shi Y, Qiao S, Bosnjak ZJ, Warltier DC, Kersten JR, Ge ZD.Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy. Sci Rep. 2016; 6:27925.

Du J, Rountree A, Lindsay K, Sadilek M, Gu H, Djukovic D, Raftery D, Contreras L, Satrústegui J, Kanow M, Sweet IR, Hurley JB. Phototransduction regulates retinal energy metabolism. J Biol Chem. 2016; 291(9):4698-710.


Du J, Linton JD, Hurley JB. Probing metabolism in the intact retina using stable isotope tracers Methods in Enzymology. 2015; 561:149-70. [Full Text]

Hurley JB, Lindsay KJ, Du J. Glucose, Lactate and shuttling of metabolites in the vertebrate retina. J Neurosci Res. 2015; 93(7):1079-92 015.

Gu H, Du J, Carnevale Neto F, Carroll PA, Turner SJ, Chiorean EG, Eisenman RN, Raftery D. Metabolomics method to comprehensively analyze amino acids in different domains. Analyst. 2015;140(8):2726-34.

Carroll PA, Diolaiti D, McFerrin L, Gu H, Djukovic D, Du J, Cheng PF, Anderson S, Ulrich M, Hurley JB, Raftery D, Ayer DE, Eisenman RN. Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis. Cancer Cell. 2015; 27(2):271-85.


Lindsay KJ*, Du J*, Sloat SR, Contreras L, Linton JD,Turner SJ,Sadilek M, Satrustegui J,Hurley JB. Pyruvate Kinase and Aspartate-Glutamate Carrier Distributions Reveal Key Metabolic Links Between Neurons and Glia in Retina. Proc Natl Acad Sci U S A. . 2014;111(43):15579-84.  *First Author.

Hurley JB, Chertov AO, Lindsay K, Giamarco M, Cleghorn W, Du J, Brockerhoff SE. Energy metabolism in the vertebrate retina. “Vertebrate Photoreceptors: Functional Molecular Bases” edited by Furukawa T, Hurley JB and Kawamura S. 2014. 91-137. Springer. (Book Chapter)

Adijanto J, Du J, Moffat C, Seifert E, Hurley JB, Philp NJ.The Retinal Pigment Epithelium utilizes Fatty Acids for Ketonegenesis: Implications for Metabolic Coupling with the Outer Retina. J Biol Chem.  2014;289(30):20570-82.


Du J, Cleghorn W, Contreras L, Linton J, Chan GC, Chertov AO, Saheki T, Govarindaju V, Sadilek M, Satrustegui J, Hurley JB. Cytosolic Reducing Power Preserves Glutamate in Retina. Proc Natl Acad Sci U S A. 2013; 288(50):36129-40.

Du J, Cleghorn W, Contreras L, Lindsay K, Rountree AM, Chertov AO, Turner SJ, Sahaboglu A, Linton J, Sadilek M, Sartrústegui J, Sweet IR, Paquet-Durand F,. Hurley JB. Inhibition of mitochondrial pyruvate transport by Zaprinast causes massive accumulation of aspartate at the expense of glutamate. J Biol Chem. 2013; 110(46):18501-6. [Full Text]

Du J*, Li Z, Li Q, Guan T, Yang Q, Xu H, Pritchard KA Jr., Camara AK, Shi Y*. Enoyl CoA Hydratase Domain-Containing 2, a Potential Novel Regulator of Myocardial Ischemia Injury. J Am Heart Assoc. 2013; 2(5):e000233. *Corresponding Author.

Zhang H, Jing X, Shi Y, Xu H, Du J, Guan T, Weihrauch D, Jones DW, Wang W, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr. N-Acetyl Lysyltyrosylcysteine Amide Inhibits Myeloperoxidase, a Novel Peptide Based Inhibitor. J Lipid Res. 2013; 54(11):3016-29.

Teng RJ, Du J, Afolayan AJ, Eis A, Shi Y, Konduri GG. AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013; 304(1):L29-42.

2012 and before

Du J*, Teng RJ, Lawrence M, Guan T, Ge Y, Shi Y*. Identification of endogenous GTP cyclohydrolase I interacting proteins in rat tissues. PLOS One. 2012;7(3):e33991. *Corresponding Author. 

Teng RJ, Du J, Welak S, Guan T, Eis A, Shi Y, Konduri GG. Cross-Talk between NADPH Oxidase and Autophagy in Pulmonary Artery Endothelial Cells with Intrauterine Persistent Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol. 2012; 302(7):L651-63.

 Du J, Teng RJ, Guan T, Eis A, Kaul S, Konduri GG, Shi Y. The Role of Autophagy in angiogenesis in Aortic Endothelial Cells. Am J Physiol Cell Physiol. 2012; 302(2):C383-91.

An J*, Du J*, Wei N, Guan T, Camara AK, Shi Y. Differential Sensitivity to LPS-Induced Myocardial Dysfunction in the Isolated Brown Norway and Dahl S Rat Hearts: Roles of Mitochondrial function, NFκB Activation and TNF-α Production. Shock. 2012; 37(3):325-32. * Co-first author.

Vladic N, Ge ZD, Leucker T, Brzezinska AK, Du JH, Shi Y, Warltier DC, Pratt PF Jr, Kersten JR. Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2011; 301(5):H2130-9.

Teng RJ, Du J, Xu H, Bakhutashvili I, Eis A, Shi Y, Pritchard KA Jr, Konduri GG. Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol. 2011; 301(3):L334-45.

Du JH, An JZ, Wei N, Guan TJ, Pritchard KA, Shi Y. Increased resistance to LPS-induced myocardial dysfunction in the Brown Norway rats vs. Dahl S rats: roles of inflammatory cytokines and NFκB pathway. Shock. 2010; 33(3):332-6.

Amour J, Brzezinska AK, Jager Z, Sullivan C, Weihrauch D, Du J, Vladic N, Shi Y, Warltier DC, Pratt PF Jr, Kersten JR. Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90­mediated mechanisms. Anesthesiology. 2010; 112(3):576-85.

Du J, Wei N , Xu H Vasquez-Vivar J, Guan T, Oldham KT, Prichard KA, Shi Y. Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I. Arterioscler Thromb Vasc Biol. 2009; 29(12):2161-8.

An J, Du J, Wei N, Xu H, Pritchard KA, Shi Y. Role of tetrahydrobiopterin in resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat. Am J Physiol Heart Circ Physiol. 2009; 297(5):H1783-91 28.

Du J*, Wei N, Guan T Pritchard KA, Shi Y*. Inhibition of CDKS by roscovitine suppressed LPS-induced *NO production through inhibiting NFkappaB activation and BH4 biosynthesis in macrophages. Am. J. Physiol. Cell Physiol. 2009; 297(3): C742-9. *Co-Corresponding author.

Du J, Xu H, Wei N, Wakim B, Halligan B, Pritchard KA Jr, Shi Y. Identification of proteins interacting with GTP cyclohydrolase I. Biochem Biophys Res Commun. 2009; 385(2): 143-7.

Chen C, Du J, Feng W, Song Y, Lu Z, Xu M, Li Z, Zhang Y. β-adrenergic receptors stimulate interleukin-6 production through Epac-dependent activation of PKCδ/p38 MAPK signaling in neonatal mouse cardiac fibroblasts. Br J Pharmacol. 2012; 166(2):676-88.

Du J, Guan T, Zhang H, Xia Y, Liu F, Zhang Y. Inhibitory crosstalk between ERK and AMPK in the growth and proliferation of cardiac fibroblasts. Biochem Biophys Res Commun. 2008; 368(2):402-7.

Gong K, Li Z, Xu M, Du J, Lv Z, Zhang Y. A novel protein kinase A-independent, betaarrestin­1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2­adrenergic receptors. J Biol Chem. 2008; 283(43):29028-36.

Guan TJ, Qin FJ, Du J, Geng L, Zhang YY, Li M. AICAR inhibits proliferation and induced S-phase arrest, and promotes apoptosis in CaSki cells. Acta Pharmacol Sin. 2007; 28(12): 1984-90.

Gong KZ, Zhang H, Du J, Zhang YY. Crosstalk between signaling pathways of adrenoreceptors and signal transducers and activators of transcription 3 (STAT3) in heart. Acta Pharmacol Sin. 2007; 28(2):153-65.

Quan Y, Du J, Wang X. High glucose stimulates GRO secretion from rat microglia ROS, PKC, and NF-kappaB pathways. J Neurosci Res. 2007; 85(14):3150-9.

Du J, Guan TJ, Zhang H, Xiao H, Han QD, Zhang YY. Phenylarsine oxide inhibited beta­adrenergic receptor-mediated IL-6 secretion: inhibition of cAMP accumulation and CREB activation in cardiac fibroblasts. Biochem Biophys Res Commun. 2007; 352(3):744.

Yin F*, Wang YY*, Du J*, Li C, Lu ZZ, Han C, Zhang YY. Noncanonical cAMP pathway and p38 MAPK mediate beta2 -Adrenergic receptor-induced IL-6 production in neonatal mouse cardiac fibroblasts. J Mol Cell Cardiol. 2006; 40(3):384-93. * Co-first author.

Du J, Xu N, Song Y, Xu M, Lu ZZ, Han C, Zhang YY. AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a possible role for AMPK. Biochem Bioph Res Co. 2005; 337(4): 1139-1144. [Link

 Du J, Liao W, Wang Y, Han C, Zhang Y. Inhibitory effect of 14-3-3 proteins on serum induced proliferation of cardiac fibroblasts. Eur J Cell Biol. 2005; 84:843-85.