Papers
UCI School of Medicine
Ophthalmology Research Seminar: Distinguished Speaker Series
Distinguished Speaker Series | UCI Center for Translational Vision Research
A. Retinal Biochemistry and basic metabolismAMD and other neurodegeneration
- Metabolism and metabolomics_Introduction TCA cycle Basics_Hanson 2002;Sonnewald-2014-Journal_of_Neurochemistry; Serine_Hanson 2012; 13C metabolic analysis in cancer cells_Antoniewicz 2018; Ammino acid concentraion by LC MS; Mitochondria_powerhouse_2018G3P Shuttle; Metabolite sensing 2018; Metabolite measurement_Good practice; Metabolomics and isotope tracing ;Mitochondrial protein acetylation_2017; Nutrient sensing pathways 2015; FAO and EMT 2018; Protein acetylation and spermiogenesis; ACOT7 in brain 2013; Mitochondrial amino acid transporter; Ammonia metabolism in cancer 2017 Science; 8 activated molecues in metabolism 2018; Rabinowitz_Pig_2019; Fructose metabolism_Rabinowitz 2018,SUCCINATE_BROWN_FAT_THERMOGENESIS; Pyruvate carboxylase KO in liver_2019
- Reviews on (retinal) metabolism: Campello-2021-Aging-of-the-retina-molecular-and-m; Lipid turnover in retina and RPE 2022; Annurev on retinal metabolism 2021; The roles of Proline Review 2021; RPE cell biology_David William 2020 Review; Warburg Effect in the retina Review_2020; Metabolism of the Retina_1946; Retina Metabolism Review 2017; Metabolic and redox signaling in the retina, 2017; Programming the metabolism in the retina,2018; Retinal Energy demand_2017 review;Why Macular? 2018; Metabolomics in AMD 2018; Vascular supply and metabolism 2018; Neuronal Metabolism Yellen 2018;a ketoglutarate dependent dioxygenases 2018; Branch-chain amino acid in neuron 2017;AMD and lipid metabolism 2018; Ceramide and retinal degeneration 2019
- Amino Acid Metabolism Aspartate and aspargenase in tumor 2018; Cytosolic aspartate and cell survival 2018; Cancer metabolism perspective 2021; mTOR story_PNAS
- Warburg effectWarburg 1925; Inhibition of LDH in retina 2017
- Pyruvate stimulates the pigmentation and maturation in RPE cell line-IVOS 2011.
- Mitochondrial pyruvate carrier: 1) Identification-Science 2012-Rutter; Science 2012-Martinou; 2) Review: Mitochondrial Pyruvate metabolism review papers. Biochem J 2015; Cell Mol Life Sci 2014; Curr Opin Cell Biol 2015; Trends Biochem Sci 2016; 3) Recent research:MPC inhibition in neuron; MPC in myocardio IR 2016; MPC in development 2016
- Review papers on RPE special issue in Experimental Eye Research. RPE protein polarity and transport 2014.
- Transport of liquid and metabolites is an essential function of RPE cells. What transporters are expressed on RPE apical or basal side? How are metabolites transported? A proteomic MRM targeting 41 transporters on hfRPE and ARPE-19 cells, 2017; CITRATE transport in brain 2016;SLC13 Inhibitor; SLC transporters as drug target_nature Review; Sodium-Coupled transporter_Anual Review, SLC_ABCs_2013
- How to do metabolic flux analysis. Nature Protocol 2008;Lipid synthesis method 2014;Metabolomics_primer
- Nictinomide rescues the inflammation, drusen protein and complement pathway activation in AMD-patient derived iPSC-Cell Stem Cell 2017
- Proline metabolism. Inborn errors of proline metabolism 2008; proline supplementation_safe at 488 mg/kg/d 2008; Proline Phang JM 2019
- Research papers on Proline metabolism.Plasma Proline kinetics 1990;
- Mitochondrial metabolism in retinal diseases? The location of mitochondria 2008; Mitochondrial energy metabolism and light damage 2015;Mitochondrial distribution 2019 IVOS
- Glucose metabolism enzymes expression in the retina Mol Vision 2016;
- NAD metabolism NAD Metabolism and control of energy Review_Auwerx J 2015;NR supplement_Brenner 2016;
- Modeling:INCA
- Metabolism gene expression Retina-Drop Seq_Cell 2015
- Lipid: Fatty acid Analysis 2011 BBA; Cholesterol in the retina 2010; Lipoprotein composite in AMD; Lipid metabolism in AMD 2018; Lipid acetylation in histone 2016
- Retinal metabolism in other neurodegenerative diseases: Retina and Alzheimer disease 2011;Retinal changes in Alzheimer’s 2020; Occular changes in Alzherimer’s 2016; Metabolism in Alzheimer disease
- Others: How many cells in the retina?
B. Retinal Pigment Epithelium (RPE)
1. RPE cell culture. Vargi E Review on RPE culture 2016;Cell culture model 2015; Pig RPE model for Drusen
2. RPE and ECM. ECM and AMD 2014; EEEMP1 PNAS 2002; ECM and Drusen; EFEMP1 mutant mice; RPE hybrid cells;EFEMP1 KO mice without AMD; ECM genes in AMD patient2016;Deposit in RPE 1999 Arch Ophthalmol; Dynamics of Bruch 2010
3. RPE in health and disease Sparrow RPE heath and disease 2010; OMA on RPE 2016; RPE Development and injury response 2021
4. RPE and Age-related macular degeneration. Aging in different diseases 2016; Patel 2007 Genetics AMD; AMD Mouse model 2010
C. Imaging metabolism with labeled metabolites or sensors
1. Using azide-proline to image collagen in live cells. RCS 2015.
D. Diabetic Retinopathy
1. Biochemical changes in Diabetic retinopathy –JCI 2016; Temporal biochemical changes in AKITA 2017
E. Retinal Degeneration
1. Changes of metabolites in DHA, All-trans retinal and others in photoreceptor degeneration with or without RPE cells- Philos Trans A Math Phys Eng Sci. 2016.
2. Genetic diseases with macular and choroid degeneration Pediatric genetic macular and choroid disease JPG 2014
3. Age-related macular degeneration (AMD).Mitochondrial defect in AMD 2020; AMD and other neurodegeneration
F. New techniques. Imaging MS Of Retina
People behind retinal metabolism
Barry S Winkler
Professor Emeritus of Biomedical Sciences
Oakland University
Adelbert Ames III
CNS metabolism related to function 2000.
In vitro retina as an experimental model of the central nervous system.
Jin H Kinoshita
A trilogy on retinal metabolism on JBC I, II, III.
Contribution in Sorbitol metabolism
Talks
- Talks from Doheny Eye Institute http://rimr.doheny.org/resources/tutorials/
1.1 Lessons from Alzeheimer’s disease for AMD
1.5 Mitochondrial Dynamics and AMD
2. Lipids in the Eye 2020 ASBMB